Cytochrome P-450 Reductase Activities in the Liver Microsomes of Diabetic Rats Induced With Some Chemical Solvents
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چکیده
In this work, it has been attempted to determine the alterations brought about in the enzyme activities by oral administering acetone, isopropanol and ethanol to chemically induced diabetic rats. The rats in whom diabetes was induced diabetic by 65 mg/kg streptozotocin (stz) were divided into four main groups as a stz alone (group I), stz + aceton (group II), stz + isopropanol (group III), stz + ethanol (group IV) respectively. The control group was given physiological saline. Then liver microsomal fractions were obtained both from the control and experimental groups of rats. The enzyme activities were determined by using Strobel’s method.
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